A primate genome project deserves high priority.

نویسندگان

  • E H McConkey
  • A Varki
چکیده

The initial goals of the Human Genome Project (HGP), to sequence the human genome and identify its constituent genes, are on the verge of being achieved. However, the scientific community recognizes that sequencing must be followed by understanding the manifold functions of human genes throughout the life-span, in health and in disease. In a Science interview (News Focus, 31 Mar., p. 2396), Francis Collins acknowledged this by saying, “Understanding what the sequence means will require us to make multiple comparisons....The arguments are quite strong for sequencing other mammals besides human and mouse...and for doing another primate.”

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Examining priorities for a primate genome project.

Examining Priorities for a Primate Genome Project We agree with the premise of Edwin H. McConkey, Agit Varki, and cosignatories that "[a] primate genome project deserves high priority" in the U.S. biomedical research enterprise (Letters, 25 Aug., p. 1295), but we disagree with their selection of the chimpanzee as the focus for these efforts, and with the recommendation to commit resources to ge...

متن کامل

Chapter 2 “ The Case for a 500 GeV e + e − Linear Collider ” (

Several proposals are being developed around the world for an e + e − linear collider with an initial center of mass energy of 500 GeV. In this paper, we will discuss why a project of this type deserves priority as the next major initiative in high energy physics.

متن کامل

LINEs and SINEs of primate evolution.

The primate order is a monophyletic group thought to have diverged from the Euarchonta more than 65 mya. Recent paleontological and molecular evolution studies place the last common ancestor of primates even earlier (‡ 85 mya). More than 300 extant primate species are recognized today, clearly emphasizing their diversity and success. Our understanding of the evolution of primates and the compos...

متن کامل

BLAT-Based Comparative Analysis for Transposable Elements: BLATCAT

The availability of several whole genome sequences makes comparative analyses possible. In primate genomes, the priority of transposable elements (TEs) is significantly increased because they account for ~45% of the primate genomes, they can regulate the gene expression level, and they are associated with genomic fluidity in their host genomes. Here, we developed the BLAST-like alignment tool (...

متن کامل

Sequencing the Chimpanzee Genome

Sequence of the chimpanzee (Pan troglodytes) genome should be a high priority. The chimpanzee genome sequence will have a major impact on our understanding of human disease, human evolution, and human population genetics. We propose that the first phase of a project to obtain chimpanzee sequence consist of 3-4X whole-genome shotgun coverage, with the sequence obtained from multiple individuals ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Science

دوره 289 5483  شماره 

صفحات  -

تاریخ انتشار 2000